Dramatically Different Moisturizing Lotion+™ - 4.2oz / 125ml

Dramatically Different Moisturizing Lotion+™ - 4.2oz / 125ml

 (7657 Reviews)
$31.99
$31.99 $34.00
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💧 Delivers 8-Hour Hydration
The lotion provides long-lasting moisture for up to 8 hours. Its formula contains powerful humectants like pure urea and pure glycerin, which work by attracting and binding water to the skin.

🛡️ Strengthens Skin's Natural Barrier
It features a pro-lipid complex with 3 ingredients designed to support and strengthen the skin's natural moisture barrier. This helps keep skin hydrated, balanced, and resilient.

✨ Soothing & Gentle Formula
Developed with clinical expertise, this silky, fast-absorbing lotion is suitable for very dry to dry combination skin. It is 100% fragrance-free, dermatologist-tested, and allergy-tested for sensitive skin.

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I like the packaging, simple but elegant. The lotion can be safely and comfortably used when skin reacts or has allergic reactions.

Mary
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Clinique's #1 face moisturizer.

Our dermatologist-developed formula is a cult classic.One sold every 6 seconds globally.*

*Based on internal Clinique global data for Dramatically Different Moisturizing Lotion+, February 2023–January 2024.

Fast-absorbing, barrier-strengthening hydration.

This iconic moisturizing lotion is Clinique's solution for very dry to dry combination skin types. Its lightweight, non-greasy texture absorbs rapidly to deliver an immediate sensation of comfort. The formula is powered by a strategic blend of skin-identical ingredients:

  • Pure Urea & Pure Glycerin: These powerful natural humectants work in tandem to attract moisture from the environment and bind it deep within the skin's surface.
  • Pro-Lipid Complex: This blend of three essential lipids helps replenish and support the skin's natural barrier, which is crucial for locking in hydration and keeping irritants out.

The result is skin that feels supple, looks healthy, and is better equipped to maintain its optimal moisture balance over time.

Clinique's #1 trusted moisturizer for dry, sensitive skin.

  • Proven Efficacy & Trust: It's not just a moisturizer; it's Clinique's #1 best-selling face moisturizer, a testament to its reliable performance.
  • Barrier-Care Focus: It goes beyond surface hydration to actively improve skin's long-term health by reinforcing its fundamental protective layer.
  • Pure & Gentle Formula: The commitment to being 100% fragrance-free and thoroughly tested makes it a safe and smart choice for even the most reactive skin types.
  • Versatile for Target Skin Needs: Specifically engineered to deliver transformative hydration for very dry, dry, and dry combination skin.

Dermatologist-made, barrier-strengthening daily moisturizer.

Clinique's Dramatically Different Moisturizing Lotion+™ is a silky, fast-absorbing daily moisturizer designed to transform dry, uncomfortable skin into soft, resilient, and balanced skin. Created by dermatologists, its mission is simple yet powerful: to provide lasting hydration while actively strengthening the skin's own protective barrier against moisture loss.

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3 Steps to Healthy Skin

  • Step 1:Cleanse

    Clean, comfortable, refreshed skin.

    Soft, non-drying lather removes dirt and debris, and protects skin's natural moisture balance. Formulated with sucrose, it delivers a gentle and thorough clean.

  • Step 2:Exfoliate

    Gently refine skin's texture.
    Liquid exfoliator sloughs away pollutants and dead skin cells to leave behind brighter, glowing skin. In 5 skin-typed formulas for just-right, twice-daily exfoliation.

  • Step 3:Moisturize

    Skin-strengthening hydration.
    Dermatologist developed for more resilient skin. Now in two formulas.

    Clinique's #1, 8-hr, fragrance-free hydration.

    Clinique's Iconic #1 Moisturizer: The dermatologist-developed lotion that started it all, trusted for generations.

    100% Fragrance-Free & Tested for Safety: Formulated without fragrance and rigorously allergy tested and dermatologist tested, making it ideal for sensitive skin.

    8-Hour Hydration Power: Delivers continuous moisture to keep skin comfortably hydrated all day.

    Skins Barrier Strengthening Formula: Features a unique complex of pure urea, pure glycerin, and pro-lipids that works to reinforce your skin's natural moisture barrier.

    Why Clinique?

    With 55+ years of dermatological expertise, Clinique is one of the most trusted brands in the world.

    We provide dermatologist guided solutions that are all allergy tested, 100% fragrance free.

     In service of all skin.

    Dermatologist guided since 1968.

    A Vogue editor asked dermatologist Norman Orentreich: Can great skin be created? His answer: yes. And with that, Clinique—the allergy tested, 100% fragrance free skincare and makeup brand—was born.

    Powerful efficacy with rigorous safety.

    Designed with the perfect balance of ingredients, our formulas are carefully calibrated for results, yet sensitive to skin’s needs.

    Safety down to a science.

    Since day one, our formulas have been subjected to rigorous allergy testing. That means nearly 6 million test applications to date—and counting.

    Reviews

    • ★★★★★

      A Holy Grail for Dry, Sensitive Skin

      "This is my desert-island moisturizer. As someone with dry, reactive skin that breaks out from fragrances, finding this 100% fragrance-free formula was a game-changer. It absorbs instantly with no greasy residue, provides all-day comfort without irritation, and has truly helped strengthen my skin barrier over time. A reliable staple I've repurchased for years."

      KingK

    • ★★★★★

      Perfect Under Makeup

      "I've tried countless moisturizers, and this is the best base for makeup I've ever found. Its lightweight, non-greasy texture sinks right in, leaving my skin perfectly smooth and hydrated. My foundation applies evenly and lasts longer without caking or separating. It's the invisible, effective prep my routine was missing."

      Racc

    • ★★★★★

      Transformed My Rough, Flaky Patches

      "My cheeks and forehead used to get so flaky, no matter what I tried. This lotion fixed it within a week. The combination of urea and glycerin delivers deep hydration that lasts, while the pro-lipids seem to repair my skin's ability to hold onto moisture. My complexion is now consistently soft and supple—no more rough patches!"

      Anne

    • ★★★★★

      Ideal for Men's Skincare Routine

      "I wanted a simple, effective moisturizer without a heavy scent or sticky feel. This product nails it. It absorbs in seconds after I shave, soothing my skin without any sting or shine. The bottle lasts forever, and the clinical, no-nonsense branding is a plus. It just works, without any fuss."

      Fran

    • ★★★★★

      Saved My Skin During Winter

      "When winter hits, my skin gets tight, itchy, and painfully dry. This lotion is my savior. The '8-hour hydration' claim is real—it gets me through the entire workday in a dry office. A few bottles later, my skin barrier feels more resilient against the harsh weather. It's my essential winter skincare armor."

      Stacyr

    • ★★★★★

      Worth Every Penny

      "Yes, it's an investment, but the value is incredible. The large 6.7oz bottle lasts me over six months with daily use. Given how effective it is at hydrating and calming my dry combination skin, the cost per use is minimal. It's a premium product that delivers premium, long-term results. I'll never switch."

      Candy

      Frequently Asked Questions

      Who is this moisturizer best suited for?

      This lotion is specifically formulated forvery dry, dry, and dry combination skin types. Its 100% fragrance-free and allergy-tested formula also makes it an excellent and gentle choice for those withsensitive or reactive skin.

      What are the key ingredients and what do they do?

      The formula is built around a trio of effective ingredients:

      • Pure Urea & Pure Glycerin: These are powerful humectants that attract moisture from the air and bind it to your skin to provide deep, long-lasting hydration.
      • Pro-Lipid Complex: This blend of lipids helps to reinforce your skin's natural moisture barrier, which is essential for locking in hydration and protecting against irritants.

      How should I use this product in my skincare routine?

      Apply it to clean skinevery morning and evening. It is designed as the third step in Clinique's foundational 3-Step Skin Care System (Cleanse, Exfoliate, Moisturize). Use it alone or as a perfect, non-greasy base before sunscreen and makeup.

      Is this product non-comedogenic? Will it clog my pores?

      While the official product page does not explicitly label it as "non-comedogenic," it isdermatologist-developed, allergy-tested, and oil-free. Its lightweight, fast-absorbing formula is designed to hydrate without leaving a heavy, pore-clogging residue, making it suitable for dry combination skin types.

      Can I use this moisturizer if I have acne-prone skin?

      If your acne-prone skin is alsodry or sensitive, this fragrance-free, gentle formula can be a good hydrating option that is less likely to cause irritation. However, if your primary concern is oiliness and breakouts, you may want to explore Clinique's gel-based moisturizers which are specifically designed for oily to combination skin types.

      What size options are available?

      The product comes in multiple sizes for convenience and travel:6.7oz / 200ml(the standard large bottle),4.2oz / 125ml,1.7oz / 50ml, and a0.5oz / 15ml travel size. Please note that the travel size is often excluded from promotional discounts.